解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Intestinal peristalsis is a dynamic physiologic process influenced by dietary and microbial changes. It is tightly regulated by complex cellular interactions; however, our understanding of these controls is incomplete. A distinct population of macrophages is distributed in the intestinal muscularis externa. We demonst...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2014.04.050
更新日期:2014-07-17 00:00:00
abstract::Toxic DNA-protein crosslinks (DPCs) arise by ionizing irradiation and UV light, are particularly caused by endogenously produced reactive compounds such as formaldehyde, and also occur during compromised topoisomerase action. Although nucleotide excision repair and homologous recombination contribute to cell survival ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2014.04.053
更新日期:2014-07-17 00:00:00
abstract::DNA transcription, replication, and repair are regulated by histone acetylation, a process that requires the generation of acetyl-coenzyme A (CoA). Here, we show that all the subunits of the mitochondrial pyruvate dehydrogenase complex (PDC) are also present and functional in the nucleus of mammalian cells. We found t...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2014.04.046
更新日期:2014-07-03 00:00:00
abstract::The dynamic synapse is represented by the constant mobility and exchange of components at both the cell surface and at intracellular sites. This includes thermally powered Brownian diffusion movement, followed by reversible trapping through receptor-scaffold interactions and active transport of cargo vesicles through ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2014.06.002
更新日期:2014-06-19 00:00:00
abstract::Clec16a has been identified as a disease susceptibility gene for type 1 diabetes, multiple sclerosis, and adrenal dysfunction, but its function is unknown. Here we report that Clec16a is a membrane-associated endosomal protein that interacts with E3 ubiquitin ligase Nrdp1. Loss of Clec16a leads to an increase in the N...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2014.05.016
更新日期:2014-06-19 00:00:00
abstract::Excessive sun tanning can result in addictive behavior. In this issue of Cell, Fell et al. utilize a combination of behavioral pharmacology and transgenic mice to demonstrate that chronic UV light exposure recruits p53 signaling in keratinocytes, subsequently increasing β-endorphin signaling at opioid receptors, and p...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2014.06.009
更新日期:2014-06-19 00:00:00
abstract::The Hippo-signaling pathway is an important regulator of cellular proliferation and organ size. However, little is known about the role of this cascade in the control of cell fate. Employing a combination of lineage tracing, clonal analysis, and organoid culture approaches, we demonstrate that Hippo pathway activity i...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2014.03.060
更新日期:2014-06-05 00:00:00
abstract::Chromatin modifying activities inherent to polycomb repressive complexes PRC1 and PRC2 play an essential role in gene regulation, cellular differentiation, and development. However, the mechanisms by which these complexes recognize their target sites and function together to form repressive chromatin domains remain po...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2014.05.004
更新日期:2014-06-05 00:00:00
abstract::Receptor-interacting protein kinase (RIPK)-1 is involved in RIPK3-dependent and -independent signaling pathways leading to cell death and/or inflammation. Genetic ablation of ripk1 causes postnatal lethality, which was not prevented by deletion of ripk3, caspase-8, or fadd. However, animals that lack RIPK1, RIPK3, and...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2014.04.018
更新日期:2014-05-22 00:00:00
abstract::RECQL5 is the sole member of the RECQ family of helicases associated with RNA polymerase II (RNAPII). We now show that RECQL5 is a general elongation factor that is important for preserving genome stability during transcription. Depletion or overexpression of RECQL5 results in corresponding shifts in the genome-wide R...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2014.03.048
更新日期:2014-05-22 00:00:00
abstract::E-cadherin is a major homophilic cell-cell adhesion molecule that inhibits motility of individual cells on matrix. However, its contribution to migration of cells through cell-rich tissues is less clear. We developed an in vivo sensor of mechanical tension across E-cadherin molecules, which we combined with cell-type-...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2014.03.045
更新日期:2014-05-22 00:00:00
abstract::Developmental signaling pathways needed to evolve to be robust against environmental fluctuations. In this issue, Shimizu et al. reveal a complex system of interacting endocytic pathways that help to maintain consistent levels of Notch activity across a range of temperatures. ...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2014.05.007
更新日期:2014-05-22 00:00:00
abstract::Fragile X syndrome, a common form of inherited intellectual disability, is caused by loss of the fragile X mental retardation protein FMRP. FMRP is present predominantly in the cytoplasm, where it regulates translation of proteins that are important for synaptic function. We identify FMRP as a chromatin-binding protei...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2014.03.040
更新日期:2014-05-08 00:00:00
abstract::Cardiomyocytes, the cells of the heart muscle, lose nearly all of their proliferative capacity after birth, limiting the heart's ability to regenerate. Naqvi et al. now identify a transient burst of cardiomyocyte proliferation during preadolescence, driven by a thyroid hormone surge, with therapeutic implications for ...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2014.04.025
更新日期:2014-05-08 00:00:00
abstract::Neurodegenerative diseases can occur so early as to affect neurodevelopment. From a cohort of more than 2,000 consanguineous families with childhood neurological disease, we identified a founder mutation in four independent pedigrees in cleavage and polyadenylation factor I subunit 1 (CLP1). CLP1 is a multifunctional ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2014.03.049
更新日期:2014-04-24 00:00:00
abstract::Tumor suppressors block the development of cancer and are often lost during tumor development. Papa et al. show that partial loss of normal PTEN tumor suppressor function can be compounded by additional disruption caused by the expression of inactive mutant PTEN protein. This has significant implications for patients ...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2014.04.008
更新日期:2014-04-24 00:00:00
abstract::Maintenance of a constant cell volume in response to extracellular or intracellular osmotic changes is critical for cellular homeostasis. Activation of a ubiquitous volume-regulated anion channel (VRAC) plays a key role in this process; however, its molecular identity in vertebrates remains unknown. Here, we used a ce...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2014.03.024
更新日期:2014-04-10 00:00:00
abstract::The looming threat of a new influenza virus pandemic has fueled ambitious efforts to devise more predictive parameters for assessing the risks associated with emergent virus strains. At the same time, a comprehensive understanding of critical factors that can accurately predict the outcome of vaccination is sorely nee...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2014.03.023
更新日期:2014-04-10 00:00:00
abstract::Isolation of genes encoding the receptors for steroids, retinoids, vitamin D, and thyroid hormone and their structural and functional analysis revealed an evolutionarily conserved template for nuclear hormone receptors. This discovery sparked identification of numerous genes encoding related proteins, termed orphan re...
journal_title:Cell
pub_type: 杂志文章,评审
doi:10.1016/j.cell.2014.03.012
更新日期:2014-03-27 00:00:00
abstract::Cell differentiation is an essential process for the development, growth, reproduction, and longevity of all multicellular organisms, and its regulation has been the focus of intense investigation for the past four decades. The study of natural and induced stem cells has ushered an age of re-examination of what it mea...
journal_title:Cell
pub_type: 杂志文章,评审
doi:10.1016/j.cell.2014.02.041
更新日期:2014-03-27 00:00:00
abstract::Synonymous mutations change the sequence of a gene without directly altering the sequence of the encoded protein. Here, we present evidence that these "silent" mutations frequently contribute to human cancer. Selection on synonymous mutations in oncogenes is cancer-type specific, and although the functional consequenc...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2014.01.051
更新日期:2014-03-13 00:00:00
abstract::Models of transcription are often built around a picture of RNA polymerase and transcription factors (TFs) acting on a single copy of a promoter. However, most TFs are shared between multiple genes with varying binding affinities. Beyond that, genes often exist at high copy number-in multiple identical copies on the c...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2014.02.022
更新日期:2014-03-13 00:00:00
abstract::Aging entails a progressive decline in protein homeostasis, which often leads to age-related diseases. The endoplasmic reticulum (ER) is the site of protein synthesis and maturation for secreted and membrane proteins. Correct folding of ER proteins requires covalent attachment of N-linked glycan oligosaccharides. Here...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2014.01.061
更新日期:2014-03-13 00:00:00
abstract::Mucus production by goblet cells of the large intestine serves as a crucial antimicrobial protective mechanism at the interface between the eukaryotic and prokaryotic cells of the mammalian intestinal ecosystem. However, the regulatory pathways involved in goblet cell-induced mucus secretion remain largely unknown. He...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2014.01.026
更新日期:2014-02-27 00:00:00
abstract::Biological membranes undergo constant remodeling by membrane fission and fusion to change their shape and to exchange material between subcellular compartments. During clathrin-mediated endocytosis, the dynamic assembly and disassembly of protein scaffolds comprising members of the bin-amphiphysin-rvs (BAR) domain pro...
journal_title:Cell
pub_type: 杂志文章,评审
doi:10.1016/j.cell.2014.02.017
更新日期:2014-02-27 00:00:00
abstract::TOR complex 1 (TORC1) is a potent anabolic regulator of cellular growth and metabolism. When cells have sufficient amino acids, TORC1 is active due to its lysosomal localization mediated via the Rag GTPases. Upon amino acid removal, the Rag GTPases release TORC1, causing it to become cytoplasmic and inactive. We show ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2014.01.024
更新日期:2014-02-13 00:00:00
abstract::Finding a cell that reprograms in a nonstochastic manner without genetic manipulation has proven elusive. In this issue, Guo et al. report the identification of a cell defined by an ultrafast cycle whose progeny reprogram in a synchronous and rapid manner. ...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2014.01.046
更新日期:2014-02-13 00:00:00
abstract::Vascular permeability is frequently associated with inflammation and is triggered by a cohort of secreted permeability factors such as vascular endothelial growth factor (VEGF). Here, we show that the physiological vascular permeability that precedes implantation is directly controlled by progesterone receptor (PR) an...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2013.12.025
更新日期:2014-01-30 00:00:00
abstract::Rare diseases are powerful windows into biological processes and can serve as models for the development of therapeutic strategies. The progress made on the premature aging disorder Progeria is a shining example of the impact that studies of rare diseases can have. ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2013.12.028
更新日期:2014-01-30 00:00:00
abstract::Sleep is characterized by behavioral quiescence, homeostasis, increased arousal threshold, and rapid reversibility. Understanding how these properties are encoded by a neuronal circuit has been difficult, and no single molecular or neuronal pathway has been shown to be responsible for the regulation of sleep. Taking a...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2013.11.036
更新日期:2014-01-16 00:00:00
abstract::During adaptive angiogenesis, a key process in the etiology and treatment of cancer and obesity, the vasculature changes to meet the metabolic needs of its target tissues. Although the cues governing vascular remodeling are not fully understood, target-derived signals are generally believed to underlie this process. H...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2013.12.008
更新日期:2014-01-16 00:00:00
abstract::The HIV auxiliary protein Vpr potently blocks the cell cycle at the G2/M transition. Here, we show that G2/M arrest results from untimely activation of the structure-specific endonuclease (SSE) regulator SLX4 complex (SLX4com) by Vpr, a process that requires VPRBP-DDB1-CUL4 E3-ligase complex. Direct interaction of Vpr...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2013.12.011
更新日期:2014-01-16 00:00:00
abstract::Microglia are the resident macrophages of the CNS, and their functions have been extensively studied in various brain pathologies. The physiological roles of microglia in brain plasticity and function, however, remain unclear. To address this question, we generated CX3CR1(CreER) mice expressing tamoxifen-inducible Cre...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2013.11.030
更新日期:2013-12-19 00:00:00
abstract::TET-mediated 5-methyl cytosine (5mC) oxidation acts in epigenetic regulation, stem cell development, and cancer. Hu et al. now determine the crystal structure of the TET2 catalytic domain bound to DNA, shedding light on 5mC-DNA substrate recognition and the catalytic mechanism of 5mC oxidation. ...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2013.12.002
更新日期:2013-12-19 00:00:00
abstract::The treatment of advanced prostate cancer has been transformed by novel antiandrogen therapies such as enzalutamide. Here, we identify induction of glucocorticoid receptor (GR) expression as a common feature of drug-resistant tumors in a credentialed preclinical model, a finding also confirmed in patient samples. GR s...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2013.11.012
更新日期:2013-12-05 00:00:00
abstract::IFN-γ-activated macrophages attempt to limit pathogen growth through tryptophan starvation. Zhang et al. demonstrate that Mycobacterium tuberculosis responds to this threat by synthesizing its own tryptophan. Genetic and chemical inhibition of this pathway reduces mycobacterial survival, revealing a new immune-depende...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2013.11.015
更新日期:2013-12-05 00:00:00
abstract::The low-complexity (LC) domains of the products of the fused in sarcoma (FUS), Ewings sarcoma (EWS), and TAF15 genes are translocated onto a variety of different DNA-binding domains and thereby assist in driving the formation of cancerous cells. In the context of the translocated fusion proteins, these LC sequences fu...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2013.10.033
更新日期:2013-11-21 00:00:00
abstract::Nucleosome assembly following DNA replication and gene transcription is important to maintain genome stability and epigenetic information. Newly synthesized histones H3-H4 first bind histone chaperone Asf1 and are then transferred to other chaperones for nucleosome assembly. However, it is unknown how H3-H4 is transfe...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2013.10.014
更新日期:2013-11-07 00:00:00
abstract::ATP-dependent proteases are vital to maintain cellular protein homeostasis. Here, we study the mechanisms of force generation and intersubunit coordination in the ClpXP protease from E. coli to understand how these machines couple ATP hydrolysis to mechanical protein unfolding. Single-molecule analyses reveal that pho...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2013.09.022
更新日期:2013-10-24 00:00:00
abstract::During HIV infection, the timing of opportunistic infections is not always associated with severity of CD4 T cell depletion, and different opportunistic pathogens reactivate at different CD4 T cell thresholds. Here, we examine how differences in the phenotype and function of pathogen-specific CD4 T cells influence sus...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2013.09.045
更新日期:2013-10-24 00:00:00